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. 2020 May 15;16(5):e1008516. doi: 10.1371/journal.ppat.1008516

Fig 4. B. burgdorferi producing OspC variants differ in their ability to bind to fibronectin and dermatan sulfate.

Fig 4

Binding of radiolabeled B. burgdorferi B31-A3/pBSV2G (“B31-A3/Vector”), ospC-deficient strain B31-A3ΔospC/pBSV2G (“Vector”), or the deletion strain bearing a plasmid encoding the indicated OspC variants to BSA (Top panel), fibronectin (Middle panel), or dermatan sulfate (DS) (Bottom panel) was determined (see Materials and Methods). Each bar represents the mean of four independent determinations ± SEM. Statistical significance was determined using ANOVA with the Kruskal-Wallis test followed by the two-stage step-up method of Benjamini, Krieger and Yekutieli. Significant (p < 0.05) differences in binding relative to the OspC-deficient strain B31-A3ΔospC/pBSV2G (‘‘*”) or between two strains relative to each other (‘‘+”) are indicated.