Table 1.

Changes in symptoms overall and association with increase in number of cracks and with baseline treatment recommendations for the 1,850 subjects with one-year follow up data.

			Baseline recommendation
	All		Monitor (N=1,601)		Treatment (N=249)			Any increase in # of cracks (N = 106)
Change in symptoms	N¹	%²	N¹	%²	N¹	%²	P⁴	N	Row %	p⁴
Any changes in symptoms							<0.001			0.7
Yes	585	32%	448	28%	137	55%		36	6%
No	1,265	68%	1,153	72%	112	45%		70	6%

Any decrease in symptoms							<0.001			0.8
Yes	421	23%	310	19%	111	45%		24	6%
No (includes increases)	1,429	77%	1,291	81%	138	55%		82	6%


Any increase in symptoms							0.045			0.3
Yes	194	10%	157	10%	37	15%		15	8%
No (includes decreases)	1,656	90%	1,444	90%	212	85%		91	6%


Any symptom							<0.001			0.8
Decrease only	391	21%	291	18%	100	40%		21	5%
Both increase & decrease	30	2%	19	1%	11	4%		3	10%
No change	1,265	68%	1,153	72%	112	45%		70	6%
Increase only	164	9%	138	9%	26	10%		12	7%


Cold pain							0.001			0.9
Decrease	286	16%	219	14%	67	27%		15	5%
No change	1,386	76%	1,232	77%	154	62%		78	6%
Increase	145	8%	122	8%	23	9%		10	7%


Bite pain							<0.001			0.6
Decrease	117	6%	69	4%	48	19%		8	7%
No change	1,667	91%	1,483	93%	184	74%		93	6%
Increase	42	2%	31	2%	11	4%		4	10%


Spontaneous							<0.001			0.14
Decrease	123	7%	78	5%	45	18%		4	3%
No change	1,693	91%	1,497	94%	196	79%		100	6%
Increase	34	2%	26	2%	8	3%		2	6%


# Symptom types increased							0.045			0.4
0	1,656	90%	1,444	90%	212	85%		91	6%
1	173	9%	141	9%	32	13%		14	8%
2	15	1%	10	1%	5	2%		1	7%
3	6	<1%	6	0%	0	0%		0	0%


# Symptom types decreased							<0.001			0.4
0	1,429	77%	1,291	81%	138	55%		82	6%
1	337	18%	264	16%	73	29%		21	6%
2	63	3%	36	2%	27	11%		3	5%
3	21	1%	10	1%	11	4%		0	0%

Column Ns not summing to column total N above due to missing data (33 and 24 missing changes in cold and biting pain, respectively).

Column percents not summing to 100 due to rounding.