Table 2.
Outcomes of DFI With Individual MDRO (Within 1 Year)
| Entire Cohort | PA (n = 94) | Non-PA (n = 554) | ORa (95% CI) | Adjusted HR (95% CI) | 3GCR-EC (n = 51) | Non- 3GCR-EC (n = 597) | ORa (95% CI) | Adjusted HR (95% CI) | VRE (n = 52) | Non-VRE (n = 596) | ORa (95% CI) | Adjusted HR (95% CI) | DFI- MRSA (n = 224) | DFI-Non- MRSA (n = 424) | ORa (95% CI) | Adjusted HR (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Recurrent DFI | 125 (19.3) | 24 (25.5) | 101 (18.3) | 1.54 (0.92–2.56) | 1.55 (0.88–2.74) | 14 (27.5) | 111 (18.6) | 1.66 (0.87–3.17) | 2.95 (1.25–6.98) | 17 (32.7) | 108 (18.1) | 2.19 (1.19– 4.06) | 2.57 (1.29–5.12) | 53 (23.7) | 72 (17.0) | 1.52 (1.02– 2.26) | 1.47 (0.99–2.18) |
| LEA, No. (%) | 88 (13.6) | 21 (22.3) | 67 (12.1) | 2.09 (1.21–3.62) | 1.59 (0.88–2.89) | 17 (33.3) | 71 (11.9) | 3.70 (1.97–6.97) | 2.28 (0.93–5.62) | 12 (23.1) | 76 (12.8) | 2.05 (1.03– 4.09) | 1.50 (0.72–3.09) | 28 (12.5) | 60 (14.2) | 0.87 (0.54– 1.40) | 0.84 (0.52–1.35) |
| Less extensive amputation, No. (%) | 315 (48.6) | 42 (44.7) | 273 (49.3) | 0.83 (0.54–1.29) | 1.09 (0.66–1.79) | 19 (37.3) | 296 (49.6) | 0.60 (0.33–1.09) | 1.11 (0.48–2.53) | 25 (40.1) | 290 (48.7) | 0.98 (0.55– 1.72) | 1.10 (0.59–2.05) | 105 (46.9) | 210 (49.5) | 0.89 (0.65– 1.24) | 0.92 (0.67–1.28) |
| Readmissions, No. (%) | 391 (60.3) | 63 (67.0) | 328 (59.2) | 1.40 (0.88–2.22) | 1.04 (0.62–1.74) | 32 (62.8) | 359 (60.1) | 1.11 (0.62–2.01) | 1.34 (0.54–3.31) | 38 (73.1) | 353 (59.2) | 1.87 (0.99– 3.52) | 1.42 (0.70–2.86) | 138 (61.6) | 253 (59.7) | 1.08 (0.78– 1.51) | 1.10 (0.78–1.53) |
| Length of stay, median (IQR), d | 8 (5 to 12) | 10 (6 to 15) | 8 (5 to 12) | 0.009 | 4.5 (−3 to 12.7) | 11 (7 to 18) | 8 (5 to 12) | P< .001 | 6.6 (−5.3 to 20.2) | 7.5 (5 to 13.5) | 8 (5 to 12) | P = .98 | −1.7 (−10.6 to 8) | 8 (6 to 12) | 8 (5 to 12) | P = .06 | 5.5 (0.3 to 11) |
| Mortality (n = 535), No. (%) | 36 (6.7) | 7 (8.3) | 29 (6.4) | 1.32 (0.56–3.12) | 0.65 (0.25–1.73) | 8 (19.1) | 28 (5.7) | 3.90 (1.65–9.21) | 1.02 (0.22–4.72) | 4 (9.1) | 32 (6.5) | 1.43 (0.48– 4.25) | 1.01 (0.32–3.17) | 9 (5) | 27 (7.7) | 0.63 (0.29– 1.36) | 0.63 (0.29–1.36) |
Abbreviations: 3GCR-EC, third-generation resistant Enterobacteriaceae; CI, confidence interval; DFI, diabetic foot infection; LEA, lower extremity amputation; LOS, length of stay; MDRO, multidrug-resistant organism; MRSA, methicillin-resistant Staphylococcal aureus; OR, odds ratio; PA, Pseudomonas aeruginosa; VRE, vancomycin-resistant Enterococcus.
aFor continuous variables, P values are presented instead of odds ratios (ie, age, Charlson score, ankle-brachial index, hemoglobin A1C, length of stay, duration of treatment).