FIGURE 4.

Foxp3⁺ regulatory T‐cells were assessed by immunohistochemistry in the tumor specimens at first and second surgery (Figure 3 showed small bowel adenocarcinoma). In dogs receiving surgery and toceranib phosphate, the median number of Foxp3⁺ Treg at baseline and follow‐up were 18.5 and 11.2 cells per high power field (HPF), respectively, and follow‐up significantly decreased when compared to baseline (P = .04, A). In dogs receiving surgery alone, the median of baseline and follow‐up were 16.3 and 17.2 cells per HPF, respectively, and there was no significant between baseline and follow‐up (P = .74, B)