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. 2020 Apr 8;34(3):1272–1281. doi: 10.1111/jvim.15768

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© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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HIF‐1α⁺ cells were assessed by immunohistochemistry in the tumor specimens collected at first and second excision (Figure 4 showed small bowel adenocarcinoma). In dogs receiving surgery and toceranib phosphate, the median number of HIF‐1α⁺ tumor cells at baseline and follow‐up were 17.8 and 8.5 cells per high power field (HPF), respectively; there was a significant decrease at follow‐up when compared to baseline (P = .02; A). In dogs receiving surgery alone, the median of baseline and follow‐up were 17.1 and 14.4 cells per HPF, respectively; there was no significant difference between baseline and follow‐up (P = .16; B)