Table 1.
IC50 and sensitive/resistant classification of each cell line to IGF-IR inhibitor BMS-536924
| Cell type | Cell line | BMS-536924 | |
|---|---|---|---|
| IC50 (μmol/L)* | Sensitivity Classification | ||
| Ewing | TC32 | 0.055 | Sensitive |
| Ewing | LG | 0.063 | Sensitive |
| Ewing | VW | 0.101 | Sensitive |
| Ewing | TC71 | 0.119 | Sensitive |
| Ewing | RDES† | 0.123 | Sensitive |
| Ewing | Rh1 | 0.135 | Sensitive |
| Ewing | 5838 | 0.172 | Sensitive |
| Ewing | JD | 0.232 | Sensitive |
| Ewing | KAG | 2.113 | Resistant |
| Fibrosarcoma | HT1080/S | 1.409 | Resistant |
| Fibrosarcoma | SW-684 | 5 | Resistant |
| Leiomyosarcoma | SK-LMS-1 | 0.5 | Resistant |
| Liposarcoma | HTB-92 | 0.584 | Resistant |
| Liposarcoma | SA-4 | 0.779 | Resistant |
| Malignant Pleural Mesothelioma | H2052 | 0.403 | Resistant |
| Malignant Pleural Mesothelioma | H211 | 0.418 | Resistant |
| Malignant Pleural Mesothelioma | H513 | 3.117 | Resistant |
| Malignant Pleural Mesothelioma | H2595 | 5 | Resistant |
| Neuroblastoma | LAN-1 | 0.136 | Sensitive |
| Neuroblastoma | SHSY5Y | 0.149 | Sensitive |
| Neuroblastoma | SK-NAS | 0.192 | Sensitive |
| Neuroblastoma | SK-NSH | 0.196 | Sensitive |
| Neuroblastoma | IMR-32 | 0.277 | Sensitive |
| Rhabdomyosarcoma | Rh4† | 0.027 | Sensitive |
| Rhabdomyosarcoma | Rh41 | 0.069 | Sensitive |
| Rhabdomyosarcoma | ME | 0.163 | Sensitive |
| Rhabdomyosarcoma | CTR | 0.37 | Resistant |
| Rhabdomyosarcoma | Rh36 | 1.6 | Resistant |
NOTE: IC50 values are determined by cell proliferation assays, and the sensitivity classification cutoff is 0.35 μmol/L. Cell lines with IC50 below 0.35 μmol/L are defined as sensitive, whereas cell lines with IC50 above 0.35 μmol/L are defined as resistant to BMS-536924. The cell subtypes are indicated.
*
IC50 is the drug concentration required for 50% cell proliferation inhibition.
†
Cell lines not included in protein profiling analysis.