Table 2.

Univariate and multivariable analyses of non-pulmonary function test variables as risk factors for development of bronchiolitis obliterans syndrome.

	Univariate Analysis			Multivariable Analysis*
	Odds Ratio	95% CI	P-value	Odds Ratio	95% CI	P-value
Donor Type (vs. mismatched unrelated)
Umbilical cord	0.10	0.01–0.75	0.03
Haploidentical	0.26	0.08–0.87	0.03	0.35	0.1–1.21	0.1
Matched related	0.53	0.34–0.82	0.004	0.55	0.35–0.86	0.009
Matched unrelated	0.55	0.36–0.85	0.007	0.56	0.36–0.87	0.01
Mismatched related	0.26	0.03–1.97	0.19
Conditioning (vs. myeloablative + TBI)
Myeloablative, no TBI	0.64	0.42–0.97	0.04	0.69	0.45–1.10	0.09
Non myeloablative**	0.92	0.65–1.29	0.62
CMV serostatus match (vs. recipient negative/donor negative)
Negative/positive	0.90	0.54–1.50	0.69
Positive/negative	0.82	0.55–1.24	0.35
Positive/positive	1.04	0.71–1.53	0.84
UC or BM graft (vs. PBSC graft)	0.51	0.30–0.85	0.009	0.58	0.33–1.03	0.06
Male donor (vs. female donor)	0.66	0.49–0.90	0.008
Recipient age	1.01	1.00–1.02	0.14
Number of respiratory viral infections	0.94	0.76–1.15	0.52
through day 80
Day +80–100 IgG level	1.01	1.0–1.01	0.03	1.01	1.0–1.01	0.03
Acute GVHD grade 2–4 (vs. grade 0–1)	1.06	0.76–1.49	0.72

^*Only variables with p ≤0.1 are shown.

^**This includes regimens utilizing total body irradiation not exceeding 300 cGray.

Abbreviations. CI: confidence interval; TBI: total body irradiation; CMV: cytomegalovirus; UC: umbilical cord; BM: bone marrow; PBSC: peripheral blood stem cell; GVHD: graft-versus-host disease