Table 4.
Multivariable analysis of pulmonary function test parameters as risk factors for development of bronchiolitis obliterans syndrome, after adjustment of factors summarized in Table 2. (Odds ratio for each 20% decrease relative to 100% predicted.)
Odds Ratio | 95% CI | P-value | |
---|---|---|---|
Pre-HCT FEF25–75% | 1.15 | 1.04–1.27 | 0.007 |
Pre-HCT FEV1 | 1.17 | 1.01–1.36 | 0.04 |
Day +80 FEF25–75% | 1.21 | 1.08–1.35 | <0.001 |
Day +80 FEV1 | 1.28 | 1.07–1.54 | 0.007 |
Abbreviations. HCT: hematopoietic cell transplant; FEF25–75: forced expiratory flow between 25–75% maximum; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 second.