. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: Curr Osteoporos Rep. 2020 Jun;18(3):189–198. doi: 10.1007/s11914-020-00572-9

Table 2.

Cell lineage of potential SSCs in regenerative conditions

Gene	Constitutively active cre or inducible creER	Tamoxifen injection	Surgery		Chase	Cell lineage
Pthrp²⁹	CreER	P6	Chondrocyte ablation	P21	Day 7	Osteoblasts
Cathepsin K³¹	Cre	–	Complete fracture	6W	Days 6, 9, and 15	Chondrocytes, osteoblasts and periosteal cells
_aSMA^{49, 50}	CreER	Day0, –1	Complete fracture	3–5M	Days 2, 6, 7, and 14	Chondrocytes and osteoblasts
Osterix⁵²	CreER	P5	Complete fracture	32W	Day 8	Chondrocytes and osteoblasts
Lepr⁵³	Cre	–	Complete fracture	2M	Days 14 and 56	Chondrocytes and osteoblasts
Cxcl12³²	CreER	Day – 7	Complete fracture	6–10W	Days 2, 7, 14, and 56	Chondrocytes and osteoblasts
			Bone marrow ablation			Chondrocytes and osteoblasts
			Drill-hole injury			Osteoblasts