Table 2.
The 58 LD-independent loci associated with ADHD, by condFDR and conjFDR analyses with educational attainment (EDU) or general intelligence (INT).
| Locus | Chr | Lead SNP | A1/A2 | Nearest Gene | Functional category | ADHD|EDU condFDR | ADHD&EDU conjFDR | ADHD|INT condFDR | ADHD&INT conjFDR | P-value ADHD | P-value EDU | P-value INT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | rs112984125 | G/A | KDM4A-AS1:ST3GAL3 | ncRNA_intronic | 5.622E-08 | 5.622E-08 | 3.898E-08 | 5.068E-04 | 1.08E-12 | 2.11E-23 | 8.61E-08 |
| 2 | 1 | rs2391734 | G/T | RNU1-130P | intergenic | 1.553E-03 | 1.923E-01 | 2.766E-02 | 1.000E+00 | 6.70E-08 | 7.81E-03 | 8.60E-01 |
| 3* | 2 | rs55748262 | G/A | PDIA6 | intergenic | 2.492E-03 | 2.492E-03 | 4.150E-03 | 4.614E-02 | 2.94E-06 | 8.45E-14 | 3.00E-04 |
| 4* | 2 | rs2676507 | G/A | RAPGEF4 | intronic | 5.955E-03 | 6.942E-03 | 2.948E-01 | 9.305E-01 | 1.09E-05 | 1.23E-06 | 5.98E-01 |
| 5* | 2 | rs79699670 | G/A | RBM45 | intronic | 6.818E-03 | 9.253E-02 | 4.494E-02 | 5.049E-01 | 2.36E-06 | 1.08E-03 | 6.23E-02 |
| 6 | 2 | rs13023832 | G/A | SPAG16:AC107218.3 | ncRNA_intronic | 9.270E-03 | 9.997E-01 | ND | ND | 9.33E-08 | 1.37E-01 | ND |
| 7 | 3 | rs4858241 | T/G | RNU6-815P | intergenic | 1.892E-04 | 1.051E-01 | 2.410E-03 | 6.905E-01 | 8.17E-09 | 1.89E-03 | 2.29E-01 |
| 8* | 3 | rs12493769 | A/G | SNRK:ANO10 | intronic | 5.161E-02 | 2.576E-01 | 9.620E-03 | 2.764E-02 | 2.09E-05 | 1.53E-02 | 1.19E-04 |
| 9* | 3 | rs28535523 | C/T | UBA7 | intronic | 4.986E-03 | 4.986E-03 | 4.721E-03 | 4.721E-03 | 8.25E-06 | 1.38E-20 | 2.65E-07 |
| 10* | 3 | rs6789751 | T/C | FOXP1 | intronic | 1.097E-02 | 1.097E-02 | 9.86E-03 | 9.86E-03 | 2.92E-05 | 1.84E-09 | 1.78E-06 |
| 11* | 3 | rs11710737 | A/G | BBX | intronic | 3.842E-03 | 1.514E-02 | 1.243E-02 | 1.132E-01 | 5.55E-06 | 1.89E-05 | 1.55E-03 |
| 12* | 3 | rs7634587 | A/G | BBX | intronic | 1.789E-02 | 2.708E-01 | 9.560E-03 | 1.755E-01 | 2.20E-06 | 2.14E-02 | 3.76E-03 |
| 13 | 4 | rs28522755 | A/G | PCDH7 | intergenic | 3.141E-02 | 8.895E-01 | 3.819E-03 | 3.442E-01 | 1.53E-07 | 7.56E-01 | 1.88E-02 |
| 14* | 4 | rs1484144 | T/C | LINC01088:NAA11 | ncRNA_intronic | 4.105E-03 | 5.372E-02 | 1.472E-01 | 9.259E-01 | 1.98E-06 | 1.61E-04 | 5.89E-01 |
| 15* | 4 | rs227372 | T/C | MANBA | intronic | 2.099E-02 | 8.693E-01 | 8.547E-04 | 1.508E-01 | 8.43E-08 | 6.00E-01 | 2.74E-03 |
| 16* | 4 | rs72678859 | C/T | RP11-255I10.1 | intergenic | 3.789E-03 | 3.789E-03 | 8.591E-02 | 5.542E-01 | 5.43E-06 | 1.94E-08 | 8.89E-02 |
| 17* | 4 | rs62338074 | T/C | GPM6A | intronic | 5.921E-03 | 2.166E-02 | 9.039E-02 | 5.079E-01 | 8.47E-06 | 2.51E-05 | 6.36E-02 |
| 18* | 5 | rs13163845 | T/C | CTD-2029E14.1 | intergenic | 3.337E-03 | 3.337E-03 | 2.509E-02 | 2.650E-01 | 4.51E-06 | 2.10E-08 | 9.58E-03 |
| 19* | 5 | rs13176429 | T/C | ZNF131 | intronic | 8.511E-03 | 2.851E-01 | 7.845E-03 | 3.211E-01 | 5.03E-07 | 2.45E-02 | 1.55E-02 |
| 20 | 5 | rs4916723 | A/C | LINC00461 | ncRNA_intronic | 5.352E-05 | 5.352E-05 | 3.122E-03 | 1.25E-04 | 1.81E-08 | 2.32E-13 | 1.44E-01 |
| 21* | 5 | rs7733142 | C/A | FAM172A | intronic | 5.508E-03 | 5.508E-03 | 2.019E-01 | 7.348E-01 | 9.62E-06 | 3.41E-08 | 2.93E-01 |
| 22* | 5 | rs12658032 | A/G | RP11-6N13.1 | ncRNA_intronic | 2.202E-04 | 2.550E-04 | 6.925E-03 | 5.183E-01 | 1.15E-07 | 3.05E-10 | 6.86E-02 |
| 23* | 6 | rs57349798 | G/A | RP1-153P14.8 | ncRNA_intronic | 4.164E-03 | 4.164E-03 | 6.048E-02 | 4.389E-01 | 6.27E-06 | 7.60E-10 | 3.86E-02 |
| 24* | 6 | rs141547796 | G/A | RP1-28O17.1 | intergenic | 2.398E-04 | 5.223E-03 | 1.622E-04 | 4.285E-03 | 9.64E-08 | 1.40E-05 | 3.44E-06 |
| 25* | 6 | rs4839923 | G/A | RP11-436D23.1 | ncRNA_intronic | 1.827E-03 | 1.827E-03 | 1.699E-03 | 1.699E-03 | 1.90E-06 | 2.46E-15 | 1.12E-08 |
| 26* | 7 | rs61409925 | G/A | MAD1L1 | intronic | 5.653E-03 | 8.469E-03 | 1.990E-01 | 9.762E-01 | 1.90E-05 | 2.31E-09 | 6.97E-01 |
| 27* | 7 | rs1978102 | C/T | CALN1 | intronic | 6.510E-03 | 6.510E-03 | 6.159E-03 | 6.159E-03 | 1.25E-05 | 1.58E-18 | 1.74E-15 |
| 28 | 7 | rs9969232 | G/A | FOXP2 | intronic | 9.586E-05 | 3.707E-03 | 1.474E-02 | 9.336E-01 | 3.87E-08 | 1.65E-06 | 6.05E-01 |
| 29* | 7 | rs3757541 | A/G | CADPS2 | intronic | 3.486E-03 | 2.106E-01 | 4.881E-02 | 9.886E-01 | 2.04E-07 | 5.72E-03 | 7.26E-01 |
| 30* | 8 | rs1532744 | A/G | ERICH1-AS1 | ncRNA_intronic | 8.935E-03 | 1.401E-01 | 1.562E-02 | 2.662E-01 | 2.07E-06 | 2.46E-03 | 9.68E-03 |
| 31* | 8 | rs4383968 | T/C | LINC00681 | ncRNA_intronic | 9.360E-03 | 9.299E-02 | 1.989E-01 | 7.216E-01 | 1.01E-05 | 1.34E-04 | 2.72E-01 |
| 32* | 8 | rs4739249 | A/C | AC009695.1 | intergenic | 3.966E-03 | 4.623E-03 | 8.431E-02 | 5.389E-01 | 5.83E-06 | 9.46E-07 | 7.96E-02 |
| 33 | 8 | rs74760947 | A/G | RP1-84O15.2 | intergenic | 5.563E-03 | 8.077E-01 | 3.271E-05 | 8.829E-03 | 1.39E-08 | 5.31E-01 | 1.38E-05 |
| 34 | 8 | rs10956838 | A/C | RP11-700E23.2 | intergenic | 1.365E-03 | 4.134E-03 | 1.260E-03 | 7.59E-03 | 1.28E-06 | 4.23E-07 | 2.63E-05 |
| 35* | 9 | rs295268 | T/C | GKAP1 | intronic | 1.955E-02 | 1.141E-01 | 6.215E-03 | 2.049E-02 | 1.27E-05 | 2.14E-03 | 6.91E-05 |
| 36* | 10 | rs3928823 | G/A | RP11-575N15.1 | intergenic | 1.855E-03 | 4.685E-02 | 7.396E-03 | 2.672E-01 | 6.66E-07 | 6.47E-05 | 9.76E-03 |
| 37* | 10 | rs220370 | T/C | KIAA1217 | intronic | 4.988E-03 | 1.471E-02 | 3.053E-01 | 1.000E+00 | 8.25E-06 | 1.13E-05 | 7.72E-01 |
| 38* | 10 | rs10786831 | T/G | SORCS3 | intronic | 5.254E-04 | 6.115E-03 | 4.544E-05 | 5.55E-03 | 1.08E-05 | 1.14E-06 | 9.51E-05 |
| 39* | 11 | rs28633403 | G/A | RPLP2 | downstream | 7.556E-03 | 2.747E-01 | 2.874E-02 | 6.374E-01 | 4.46E-07 | 1.23E-02 | 1.62E-01 |
| 40* | 11 | rs4275621 | A/G | RP11-960D24.1 | intergenic | 5.273E-04 | 2.707E-02 | 3.406E-03 | 2.781E-01 | 2.03E-07 | 3.90E-05 | 1.08E-02 |
| 41* | 11 | rs11040490 | T/G | RP11-707M1.1 | ncRNA_intronic | 3.433E-03 | 6.601E-03 | 1.216E-01 | 7.683E-01 | 1.28E-05 | 1.62E-06 | 3.41E-01 |
| 42* | 11 | rs1791794 | A/G | DAGLA | intergenic | 3.407E-03 | 3.320E-02 | 4.177E-02 | 4.803E-01 | 2.45E-06 | 4.78E-05 | 5.21E-02 |
| 43* | 12 | rs7953911 | T/C | KCNH3 | intronic | 8.496E-03 | 1.932E-02 | 8.343E-02 | 3.954E-01 | 1.66E-05 | 2.14E-05 | 2.79E-02 |
| 44* | 12 | rs10400419 | T/C | HMGA2 | intergenic | 3.522E-03 | 2.438E-02 | 6.402E-02 | 5.414E-01 | 3.41E-06 | 6.76E-05 | 8.10E-02 |
| 45 | 12 | rs1427829 | A/G | RP11-1109F11.3 | upstream | 6.962E-06 | 8.223E-03 | 4.818E-06 | 9.36E-03 | 1.35E-09 | 3.64E-06 | 3.04E-05 |
| 46* | 13 | rs66931513 | A/G | WDR95P | intergenic | 1.034E-02 | 4.857E-02 | 5.795E-03 | 2.177E-02 | 1.09E-05 | 1.29E-04 | 7.73E-05 |
| 47* | 14 | rs140802584 | A/G | CTD-2384A14.1:RP11-148E17.1 | ncRNA_intronic | 1.579E-02 | 7.490E-02 | 7.258E-03 | 2.284E-02 | 1.49E-05 | 1.22E-03 | 8.42E-05 |
| 48* | 14 | rs2300861 | C/T | AKAP6 | intronic | 1.316E-02 | 8.374E-02 | 5.016E-03 | 5.016E-03 | 9.04E-06 | 9.18E-04 | 1.85E-12 |
| 49* | 14 | rs12435486 | G/A | RP11-61O1.1 | ncRNA_intronic | 2.998E-02 | 1.251E-01 | 9.675E-03 | 9.675E-03 | 2.64E-05 | 1.44E-03 | 3.20E-07 |
| 50 | 15 | rs8039398 | T/C | SEMA6D | intronic | 1.314E-05 | 3.721E-05 | 1.061E-03 | 6.761E-01 | 2.99E-09 | 3.75E-11 | 2.09E-01 |
| 51* | 16 | rs11861310 | C/T | RP11-420N3.2 | ncRNA_intronic | 1.629E-02 | 8.850E-02 | 6.236E-03 | 6.236E-03 | 1.28E-05 | 5.66E-04 | 2.27E-06 |
| 52* | 16 | rs1428102 | G/A | RPL7P47 | upstream: downstream | 8.555E-03 | 1.043E-01 | 1.363E-01 | 7.843E-01 | 2.98E-06 | 9.10E-04 | 3.65E-01 |
| 53* | 16 | rs1369918 | G/A | CDH8 | intronic | 5.347E-03 | 3.742E-02 | 2.385E-02 | 2.534E-01 | 4.51E-06 | 1.92E-04 | 8.58E-03 |
| 54 | 16 | rs212178 | G/A | AC004158.2 | ncRNA_intronic | 3.914E-05 | 8.266E-03 | 8.681E-04 | 4.177E-01 | 1.20E-08 | 3.37E-06 | 3.30E-02 |
| 55* | 18 | rs4144756 | G/A | RP11-188I24.1 | intergenic | 5.377E-03 | 3.489E-01 | 4.708E-02 | 1.000E+00 | 1.46E-07 | 2.08E-02 | 9.11E-01 |
| 56* | 20 | rs2024568 | T/C | RPL13P2 | intergenic | 7.068E-03 | 7.068E-03 | 6.679E-03 | 2.102E-02 | 1.42E-05 | 3.37E-09 | 7.28E-05 |
| 57* | 21 | rs992936 | T/C | NEK4P1 | intergenic | 6.537E-04 | 3.910E-02 | 2.679E-04 | 3.602E-03 | 1.78E-07 | 1.45E-04 | 2.50E-06 |
| 58* | 21 | rs2898433 | C/T | YRDCP3 | intergenic | 2.915E-03 | 9.528E-03 | 1.860E-01 | 8.972E-01 | 1.04E-05 | 4.36E-06 | 5.37E-01 |
The most strongly associated SNPs in novel genomic loci associated with ADHD at condFDR/conjFDR < 0.01 (bold typeset) with EDU or INT after merging regions < 250 kb apart into a single locus. The table presents chromosomal position (Chr), nearest gene and functional category. Conditional FDR (condFDR) values are reported when ADHD is conditioned on EDU (ADHD|EDU) and when ADHD is conditioned on INT (ADHD|INT). The inverse condFDR results (EDU|ADHD and INT|ADHD) are not shown. The conjunctional FDR (conjFDR) columns report the maximum condFDR value, from each pair of condFDR analyses, for each SNP. FDR values in bold typeset are significant FDR < 0.01. P-values from the original summary statistics on ADHD (8), EDU (13) and INT (12) are also reported. P-values in bold typeset are significant p < 5.0E-8. For more details see Supplementary Table 6.
*
Indicates novel ADHD loci, defined as those not associated with ADHD in the original GWAS (8).
ND, not determined.