Table 1:
Differences in medical expenditures for treating disease conditions between real and hypothetical non-WHI scenarios over a 13-year cumulative period (2003–2015): Only Women with Hysterectomy
| Disease conditions stratified by age groups (years) | Counts of disease attributable to ET (rates in ET group minus rate in placebo) (95%LCL,95%UCL) | aCumulative medical expenditure differences between real and hypothetical non-WHI scenarios ($millions) | |
|---|---|---|---|
| Annual (95%LCL,95%UCL) | 13-Years (95%LCL,95%UCL) | ||
| Breast Cancer | |||
| 50–59 | −10109 (−4404, −15814) | −61 (−26, −95) | −792 (−345, −1239) |
| 60–69 | −15426 (−7520, −23329) | −93 (−45, −141) | −1209 (−589, −1828) |
| 70–79 | −6181 (−2250, −10110) | −37 (−13, −61) | −484 (−176, −792) |
| Coronary heart disease (CHD) | |||
| 50–59 | −15887 (−6922, −24849) | −70 (−30, −110) | −912 (−397, −1426) |
| 60–69 | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| 70–79 | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| Stroke | |||
| 50–59 | −2888 (−1259, −4516) | −17 (−7, −28,) | −216 (−94, −338) |
| 60–69 | 17355 (8461, 26245) | 100 (49, 151) | 1300 (634, 1966) |
| 70–79 | 8651 (3151, 14153) | 50 (18, 82) | 648 (236, 1060) |
| Pulmonary Embolism | |||
| 50–59 | 1446 (630, 2262) | 6 (3, 10) | 80 (35, 125) |
| 60–69 | 11569 (5643, 17499) | 49 (24, 74) | 640 (312, 968) |
| 70–79 | −6179 (−2248, −10107) | −26 (−9, −43) | −342 (−124, −559) |
| Colorectal Cancer | |||
| 50–59 | −4333 (−1888, −6778) | −59 (−26, −92) | −767 (−334, −1200) |
| 60–69 | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| 70–79 | 13599 (4953, 22247) | 185 (67, 303) | 2407 (877, 3938) |
| Hip Fracture | |||
| 50–59 | −1447 (−629, −2260) | −23 (−10, −36) | −297 (−129, −464) |
| 60–69 | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| 70–79 | −8653 (−3151, −14155) | −137 (−50, −224) | −1779 (−648, −2910) |
| Global Index | |||
| 50–59 | −37549 (−16359, −58739) | −312 (−136, −488) | −4059 (−1768, −6349) |
| 60–69 | 13495 (6577, 20410) | 112 (55, 170) | 1459 (711, 2206) |
| 70–79 | 40792 (14853, 66732) | 339 (124, 555) | 4409 (1606, 7213) |
The unit expenditure per disease based on MEPS (2003–2015) data are: $6027.91, breast cancer; $4415.65, CHD; $5761.94, stroke; $4257.01, PE; $13618.06, colorectal cancer; $15812.83, hip fracture; $8315.01, global index. The 95% CIs are obtained from repeating the analysis using the 95% CIs of the non-WHI estrogen usage trend.
The annual expenditures accrued during each year of the observation period, 2003–2015, were summed up to generate 13-year cumulative expenditures associated with treating chronic condition. A positive difference in the medical expenditures corresponds to excess cost of treatment of excess diseases. Conversely, negative differences correspond to monetary savings in medical expenditures for diseases averted.