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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Apr 9;40(6):1479–1490. doi: 10.1161/ATVBAHA.119.313775

Figure 2. MDI-2268 inhibits obesity and atherosclerosis, without affecting diet consumption.

Figure 2.

Ldlr−/− mice (n=6–7/group) were fed WD containing (●) or lacking (○) MDI-2268 for 12 weeks. Mean body weight and diet consumption were measured weekly. (A) Mean body weights. Shaded areas represent 95% confidence intervals. Differences between groups were statistically significant (P<0.05) for all data points beyond week 8. (B) Mean diet consumption, normalized to body weight - i.e. [diet consumed (g)/mouse/week]/[body weight (g)]; no statistically significant difference was achieved at any time point between groups. (C) Aortic arch, thoracic, and abdominal aorta atherosclerosis, assessed after 12 weeks of WD; *P<0.05 vs. control.