Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cell membrane-coated uricase-loaded MOF nanoparticles for the enzymatic degradation of uric acid. To fabricate the formulation, MOF-uricase cores are generated by mixing the enzyme payload with Zn2+ and 2-methylimidazole (mim), followed by coating with natural cell membrane derived from source cells such as RBCs or MΦs. The resulting membrane-coated MOF-uricase nanoparticles effectively convert uric acid into allantoin, which can help to manage conditions such hyperuricemia and gout.
