Table 3.

Change from baseline for outcome measures including spasticity, range of motion, pain, functional outcome, quality of life and GAS T score

	1 month			3 month		6 month
Spasticity (MAS) of the most frequently injected muscle in each joint, median [min-max]
Shoulder: Pectoralis major	1[0-1]	p=.04	1[0-1]	p=.04	0[0-1]	p=.15
Elbow: Biceps brachii	1[0-2]	p<.001	1[0-2]	p<.001	0[0-1]	p=.05
Wrist: Flexor Carpi	1[0-2]	p<.001	1[0-2]	p<.001	0[0-1]	p=.06
Fingers: Flexor digit superficialis	1[0-2]	p<.001	1[0-1]	p<.001	1[0-1]	p=.08
Passive Range of motions; mean ± SD
Shoulder	6.66 ±5.16	p=.001	6.1 ±4.91	p=.001	2.5 ±2.73	p=.05
Elbow	15 ±7.07	p<.001	14 ±3.02	p<.001	11 ± 8.48	p<.001
Wrist	15 ±14.14	p<.001	11 ±7.07	p<.001	7 ± 5.07	p<.001
Fingers	20 ±14.14	p<.001	17.5 ±1.6	p<.001	15 ±7.07	p<.001
Active Range of motions; mean ± SD
Shoulder	8.33 ±7.52	p=.001	7.5 ±6.12	p=.001	5 ± 4.74	p=.001
Elbow	14.5 ±7.58	p<.001	12.5 ±7.58	p<.001	1.66 ± 8.89	p<.001
Wrist	20 ±14.14	p<.001	18 ±12.5	p<.001	17.5 ±1.6	p<.001
Fingers	15 ±7.62	p<.001	12.5 ±3.53	p<.001	7.5 ± 3.53	p<.001
EVA Pain; median [min-max]	1 [0-4]	p<.001	0[0-2]	p<.001	0 [0-1]	p=.08
MFS; median[min-max]	8 [1-16]	P<.001	4.5 [0-11.5]	p<.001	.5 [0-3]	p=.05
NHP; median [min-max]	0 [0-5]	p<.001	0 [0-6]	p<.001	0 [0-3]	p=.05
BI; ; median [min-max]			5[0-15]	P<.001
SF-36; mean ± SD
PCS					4.98 ±3.47	p<.001
MCS					4.53 ±3.71	p<.001
Total					4.77 ±3.39	p<.001
GAS T score; mean ± SD			25.36 ± 8.45	p<.001

TBI: Traumatic Brain Injury, MAS: Modified Ashworth Scale, MFS: Modified Frenchay Scale, NHPT: Nine Hole Peg Test, BI: Barthel Index, PCS: Physical Composite summary, MCS: Mental Composite summary; GAS: Goal Attainment Scale