Fig. 1.

Following the timeline of the disease and correlating with the clinical, laboratory and imaging data, supported also by the first anatomopathological reports, we can distinguish two main phases: (a) the first in which the viral shedding and replication with direct cell damage predominate and (b) the second in which an exaggerated host immune response with cytokine storm triggered the inflammatory cascade. Based on this concept, we correlated clinical, laboratory and imaging data in order to use the more appropriate drug. By further dividing the patients according to the clinical picture and correlating with the diagnostic tests, the most severe forms of the disease are predominated by the host hyperimmune response and the consequent damage. However, this response begins with the earlier stages, and therefore, the timing of the treatments is critical to optimize the outcome. Finally, the dosages of the drugs are reported