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. 2020 May 28;9(5):54. doi: 10.1038/s41389-020-0242-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The levels of Suvmax (n = 121) value in were significantly higher in liver tumor than in para carcinoma tissue. b Suvmax levels were significantly higher in metastatic liver tissue (n = 32) than in non-metastatic HCC tissue (n = 84). c, d The mRNA and protein expressions of HK2, PKM2, and LDHA were much higher in HCC tumors that had more metastatic potential. e Relative glucose uptake, the rate of glycolysis and lactate production were higher in five HCC cell lines compared with normal liver cell line WRL68. f Relative PKM2 mRNA level was higher in five HCC cell lines compared with normal liver cell line WRL68. g Protein levels of HK2, PKM2, and LDHA were much higher in five HCC cell lines compared with normal liver cell line WRL68. h Overexpression of HK2, PKM2, and LDHA markedly increased wound healing capacity in Huh-7 cells. i Overexpression of HK2, PKM2, and LDHA markedly increased Matrigel invasion in Huh-7 cells. On the contrary, knockdown of HK2, PKM2, and LDHA block Matrigel invasion in HCCLM3 cells.