Table 1.
Characteristics of the included studies
ALBCG: Antibiotic-loaded bone cement group; CG: Control group.
| Study | Country | No of Joints (ALBCG:CG) | Operative Site | Cement Type | Antibiotic in cement | Systemic Antibiotic | Follow-up (Months) |
|---|---|---|---|---|---|---|---|
| Pfarr et al. (1979) | Germany | 100:100 | Hip | Palacos and Refobacin-Palacos | Gentamicin | Not mentioned | 24 |
| Wannske et al. (1979) | Germany | 274:202 | Hip | Palacos and Refobacin-Palacos | Gentamicin | Not mentioned | 29 |
| Josefsson et al. (1981) | Sweden | 821:812 | Hip | Palacos | Gentamicin (0.5 g) | Cephalotin and cephalexine, Cloxacillin, Cloxacillin and Probenecid, Dicloxacillin, Phenoxymethyl penicillin |
12–24 |
| McQueen et al. (1987) | United Kingdom | 146:149 | Hip and Knee | CMW | Cefuroxime (1.5 g) | Cefuroxime | 3 |
| McQueen et al. (1990) | United Kingdom | 201:200 | Hip and Knee | CMW | Cefuroxime (1.5 g) | Cefuroxime | 24 |
| Chiu et al. (2001) | China | 41:37 | Knee | Simplex P | Cefuroxime (2 g) | Cefazolin and gentamicin | 50 (26–88) |
| Chiu et al. (2002) | China | 178:162 | Knee | Simplex P | Cefuroxime (2 g) | Cefazolin and gentamicin | 49 (26–80) |
| Hinarejos et al. (2013) | Spain | 1465:1483 | Knee | Simplex P | Erythromycin (0.5 g) and colistin (three million units) | Cefazolin (or vancomycin if the patient had a beta-lactam allergy) | 12 |
| Huali et al. (2014) | China | 70:66 | Knee | Not mentioned | Vancomycin (1 g) | Cefazolin (or Azithromycin for patients allergic to cefazolin) | 20.6 (4–24) |