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. 2019 Aug 21;77(11):2157–2179. doi: 10.1007/s00018-019-03279-y

Table 2.

EC50 values for OR2M3 with amino acid changes at positions of a putative copper/odorant-binding pocket measured in the absence and presence of 10 µmol/L Cu2+

Receptor Agonist EC50 in the absence of Cu2+ in µmol/La EC50 in the presence of Cu2+ in µmol/La
OR2M3 T105A 3-Mercapto-2-methylpentan-1-ol 1.42 ± 0.58 0.75 ± 0.27
OR2M3 C112A 3-Mercapto-2-methylpentan-1-ol n.d. 0.86 ± 0.004
OR2M3 C203S 3-Mercapto-2-methylpentan-1-ol n.d. 3.16 ± 0.01

n.d. no detectable response up to 100 µmol/L

aMean ± SD (n = 3–5)