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. 2019 Aug 21;77(11):2157–2179. doi: 10.1007/s00018-019-03279-y

Table 5.

Amino acids constituting an odorant and copper-binding site in OR2W1

TMH segmenta AA position within TMH segmenta Mutagenesis-validated binding site positions 2-Phenyl-ethanethiol 3-Mercaptohexyl acetate Allyl phenyl acetate Validated positions in other ORs
TMH 3 8 bMet1053.33 Indirect Indirect Indirect His1053.33 [30], His1083.33 [31], Ile1053.33: [64], Met1053.33: [9], His1083.33: [106], Cys1063.33: [50, 98]
TMH 3 12 bSer1093.37 Indirect Indirect Indirect Cys1093.37: [30], Asn1093.37: [10, 94], Val1133.37: [107, 123]
TMH 3 15 bCys1123.40 Indirect Indirect Indirect Ser1123.40: [10], Ser1133.40: [50, 98, 117], Cys1163.40: [123]
TMH 6 12 bTyr2526.44 π-π staking No interaction No interaction Tyr2516.44: [10, 94], Tyr2566.44: [95], Tyr2526.44: [96]
TMH 6 19 Tyr2596.51 No interaction H-bond H-bond Tyr2606.51: [64], Tyr2586.51: [64], Tyr2596.51: [97], Tyr2606.51: [50, 98], Ser2636.51: [95]

aHORDE [81]

bProposed amino acid positions constituting an odorant-binding site according to Man et al. [88]