Table 6.
P218 urine PK parameters
| P218 dose (mg) | Amount of P218 excreted in urine (ng) at time | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0‐6 h | 6‐12 h | 12‐24 h | 24‐48 h | In 48 h | Dose recovered unchanged (%) | Clearance | ||||||||
| Geometric mean | CV | Geometric mean | CV | Geometric mean | CV | Geometric mean | CV | Geometric mean | CV | Geometric mean | CV | Geometric mean | CV | |
| 10 | 568525.1 | 55.9 | 65452.7 | 31.3 | 21132.3 | 20.7 | 18833.8 | 24.4 | 685987.1 | 44.4 | 6.88 | 44.0 | 5445.9 | 56.9 |
| 30 | 1757637.5 | 55.1 | 142613.1 | 67.2 | 50970.6 | 32.6 | 33948.2 | 30.0 | 2025482.6 | 50.1 | 6.73 | 50.6 | 4647.3 | 43.8 |
| 100 | 6432925.0 | 35.1 | 266978.0 | 36.0 | 115412.4 | 56.4 | 93966.9 | 24.7 | 6924034.7 | 34.8 | 6.92 | 34.5 | 4398.0 | 21.8 |
| 250 | 15823908.7 | 24.1 | 614413.3 | 76.2 | 204287.6 | 123.3 | 92206.9 | 482.5 | 17059380.1 | 22.0 | 6.83 | 22.0 | 4369.3 | 27.2 |
| 500 | 35188232.0 | 28.2 | 2016567.8 | 63.0 | 529863.2 | 79.2 | 340479.6 | 92.3 | 38470150.7 | 28.5 | 7.70 | 28.6 | 4975.8 | 28.2 |
| 750 | 79236662.7 | 40.8 | 2415818.1 | 116.1 | 735012.7 | 46.6 | 723125.7 | 52.3 | 84699011.0 | 36.6 | 11.31 | 36.7 | 6319.4 | 29.9 |
| 1000 | 1.2E+08 | 54.3 | 2371949.5 | 78.1 | 712410.0 | 34.1 | 809023.4 | 46.2 | 1.2E+08 | 52.3 | 11.94 | 52.6 | 6787.1 | 53.4 |
Abbreviation: CV, geometric coefficient of variation; PK, pharmacokinetic.