Table 1.
List of drugs with potential interaction with direct oral anticoagulants as found to be coprescribed in the Clinical Practice Research Datalink database
| Drugs with pharmacokinetic interaction | Drugs with pharmacodynamic interaction | |
|---|---|---|
| Strong CYP3A4 and/or P‐gp inhibitors | Moderate CYP3A4 and/or P‐gp inhibitors | |
| Ketoconazole, | Amiodarone | Antiplatelet drugs |
| Cyclosporine | Posaconazole | Ticlopidine |
| Itraconazole | Quinidine | Clopidogrel* |
| Dronedarone | Verapamil | ASA |
| Tacrolimus | Digoxin | Ticagrelor |
| Diltiazem | NSAIDs | |
| Simvastatin | SSRIs | |
| Atorvastatin | Fluoxetine | |
| Fluconazole | Paroxetin | |
| Clarithromycin | Citalopram | |
| Erythromycin | Escitalopram | |
| Sertraline | ||
| Nefazodone | ||
| SNRIs | ||
| Venlafaxine | ||
| Duloxetin | ||
ASA, acetylsalicylic acid; NSAIDs, nonsteroidal anti‐inflammatory drug; SSRIs, selective serotonin reuptake inhibitor; SNRIs, serotonin–norepinephrine reuptake inhibitor.
*
Ticragrelor, and clopidogrel are also substrate of the P‐glycoprotein transporter.