Figure 1.

Ribose‐5P is synthesized to phosphoribosyl pyrophosphate (PRPP) by PRPP‐synthetase and further to inosine monophosphate (IMP). Mycophenolic acid (MPA) inhibits inosine monophosphate dehydrogenase (IMPDH) and thereby the conversion of IMP to xanthosine monophosphate (XMP), guanosine‐5′‐monophosphate (GMP), guanosine‐5′‐diphosphate (GDP), 2′‐deoxyguanosine‐5′‐diphosphate (dGDP), guanosine‐5′‐triphosphate (GTP) and 2′‐deoxyguanosine‐5′‐triphosphate (dGTP). AMP, (d)ADP, and (d)ATP are corresponding adenosine nucleotides