Table 4.

Univariate and multivariate analysis of surgery related with inflammatory bowel disease

	Univariate Cox analysis HR (95% CI)	P	Multivariate Cox analysis HR (95% CI)	P
Proactive TDM	0.18 (0.04–0.79)	.023	0.14 (0.03–0.65)	.012
Sex (ref male)	2.28 (0.79–1.10)	.275	‐
Diagnosis (ref UC)	1.62 (0.60–4.37)	.335	‐
Perianal fistulizing disease	2.73 (1.08–6.95)	.024	3.13 (1.17–8.42)	.015
Age at diagnosis	1.25 (0.63–2.49)	.515	‐
Age at start of infliximab	1.88 (0.80–4.39)	.146	‐
CD localization (ref L1)	0.15 (0.03–0.69)	.015	‐
CD behaviour (ref B1)	1.40 (0.23–8.30)	.708	‐
UC extension (ref E1)	1.34 (0.66–2.72)	.411	‐
Concomitant use of immunomodulators	2.18 (0.49–9.63)	.303	‐
Extraintestinal manifestations	1.79 (0.67–4.78)	.244	‐

CD: Crohn's disease; CI: confidence interval; HR: hazard ratio; TDM: therapeutic drug monitoring; UC: ulcerative colitis.