Figure 1.

PEDV replicated successfully despite the induction of endogenous IFN-λ responses during late infection. (A) PEDV infection induced IFN-λ expression. IFN-λ expression was monitored in Vero E6 cells after infection with PEDV at MOIs of 0.1 and the results were normalized by the mock uninfected controls. (B,C) Kinetic curve of PEDV replication in Vero E6 cells. Vero E6 cells were inoculated with PEDV at an MOI of 0.1, and the level of PEDV infection compared to mock controls at 12, 24, and 48 h was quantified by RT-qPCR and TCID₅₀. The results were obtained from three independent experiments. Mean ± SEM, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, and NS, not significant.