Table 2.
T-test results of the features with different level in plasma from SSc compared to HC.
| Compound | t-stat | p-value | –LOG10(p) | FDR |
|---|---|---|---|---|
| 4-Aminobutyraldehyde | 20.626 | 1.71E−16 | 15.768 | 2.70E−14 |
| N-Methylethanolamine phosphate | 15.732 | 4.30E−13 | 12.367 | 3.39E−11 |
| Anandamide | 8.5994 | 6.34E−09 | 8.1982 | 2.55E−07 |
| L-Carnitine | −9.4886 | 6.46E−09 | 8.1895 | 2.55E−07 |
| 9Z_11E-13S-13-Hydroperoxyoctadeca-9_11-dienoic acid | 8.6604 | 4.88E−08 | 7.3119 | 1.33E−06 |
| 3-Methyldioxyindole | −7.7001 | 5.05E−08 | 7.2965 | 1.33E−06 |
| 7-Methyluric acid | −7.5374 | 1.07E−07 | 6.9727 | 2.40E−06 |
| Arachidonate | −6.9706 | 3.04E−07 | 6.5172 | 6.00E−06 |
| 3-Methyl-2-oxobutanoic acid | 6.9281 | 4.30E−07 | 6.3665 | 7.55E−06 |
| Urea | −6.6387 | 6.69E−07 | 6.1745 | 1.06E−05 |
| Phenylacetaldehyde | 6.7867 | 7.84E−07 | 6.1059 | 1.13E−05 |
| 5-Hydroxyindoleacetate | 5.8472 | 1.08E−05 | 4.9657 | 0.00014249 |
| Creatine | 5.6352 | 1.19E−05 | 4.9227 | 0.00014522 |
| Cortisone | −5.5075 | 2.19E−05 | 4.6593 | 0.00024732 |
| Palmitoylglycerone phosphate | 5.6637 | 2.56E−05 | 4.5917 | 0.00026969 |
| Allantoate | −5.145 | 2.80E−05 | 4.553 | 0.00027639 |
| N-Acetyl-L-aspartate | 4.938 | 4.39E−05 | 4.3579 | 0.00040771 |
| 2-Phenylacetamide | −6.016 | 7.02E−05 | 4.154 | 0.00061579 |
| LL-2_6-Diaminoheptanedioate | 5.233 | 0.00010047 | 3.998 | 0.00083545 |
| Tetralin | 4.5971 | 0.0001385 | 3.8585 | 0.0010942 |
| Trans-Cinnamate | 4.5062 | 0.00017441 | 3.7584 | 0.0013122 |
| 4-Maleylacetoacetate | 4.3634 | 0.00019949 | 3.7001 | 0.0014327 |
| L-Tryptophan | −4.2562 | 0.00026453 | 3.5775 | 0.0018172 |
| 1-Palmitoylglycerol 3-phosphate | −4.2311 | 0.00027612 | 3.5589 | 0.0018178 |
| 1-Methyladenosine | −4.1094 | 0.00040482 | 3.3927 | 0.0025585 |
| 3-Hydroxyanthranilate | −6.0887 | 0.00042674 | 3.3698 | 0.0025933 |
| L-Adrenaline | −3.8816 | 0.0006982 | 3.156 | 0.0040857 |
| 3-Dimethylaminopropyl benzoate | 4.7859 | 0.00078949 | 3.1027 | 0.004455 |
| Propanil | 5.0085 | 0.00082285 | 3.0847 | 0.0044831 |
| Stearoylglycerone phosphate | −3.7659 | 0.00091976 | 3.0363 | 0.0048441 |
| Hypoxanthine | −3.736 | 0.00098251 | 3.0077 | 0.0050076 |
| D-2-Hydroxyisocaproate | 3.722 | 0.0011592 | 2.9359 | 0.0054985 |
| 6-Hydroxymelatonin | −3.6648 | 0.0011673 | 2.9328 | 0.0054985 |
| Indole-5_6-quinone | 3.6726 | 0.0011832 | 2.9269 | 0.0054985 |
| N-Acetylmethionine | 3.6107 | 0.0013535 | 2.8685 | 0.0059476 |
| N1-Methyl-2-pyridone-5-carboxamide | −4.2214 | 0.0013551 | 2.868 | 0.0059476 |
| D-Gluconic acid | −3.8235 | 0.0014258 | 2.8459 | 0.0060886 |
| Adenine | −3.787 | 0.0018606 | 2.7303 | 0.0077362 |
| Creatinine | −3.5091 | 0.0019132 | 2.7182 | 0.0077509 |
| Retinol | −3.3348 | 0.0029065 | 2.5366 | 0.011481 |
| 5_6-Dihydrothymine | −3.4016 | 0.0031036 | 2.5081 | 0.01196 |
| 5-Phosphonooxy-L-lysine | −3.2559 | 0.0033209 | 2.4787 | 0.012493 |
| 3-Methyloxindole | −3.2515 | 0.0042893 | 2.3676 | 0.015641 |
| Zeatin | −3.1636 | 0.0043557 | 2.3609 | 0.015641 |
| Adenosine | −3.0758 | 0.0063492 | 2.1973 | 0.022293 |
| Thiocysteine | 3.0117 | 0.0069451 | 2.1583 | 0.023855 |
| Inosine | −3.5235 | 0.0080192 | 2.0959 | 0.026958 |
| 1_7-Dimethyluric acid | −2.8674 | 0.0083164 | 2.0801 | 0.027375 |
| Glycolithocholate | 2.9311 | 0.0092378 | 2.0344 | 0.029787 |
| D-Glucosamine | −3.2818 | 0.010531 | 1.9775 | 0.033279 |
| 3-Hydroxyhexobarbital | −2.8883 | 0.010945 | 1.9608 | 0.033907 |
| 6-Keto-prostaglandin F1alpha | 3.017 | 0.012337 | 1.9088 | 0.036936 |
| Dehydroepiandrosterone sulfate | 2.7262 | 0.01239 | 1.9069 | 0.036936 |
| L-Octanoylcarnitine | 3.3887 | 0.0138 | 1.8601 | 0.040378 |
| 4-Guanidinobutanoate | −2.7708 | 0.014298 | 1.8447 | 0.041073 |
| 8Z_11Z_14Z-Icosatrienoic acid | −2.9042 | 0.016084 | 1.7936 | 0.045379 |
ncSSc, non-cutaneous SSc; lcSSc, limited cutaneous SSc; dcSSc, diffuse cutaneous SSc.