Table 1.
Clinical Characteristics and Laboratory Markers for the 79 HSCT Recipients.a
| Characteristics | Non TA-TMA (n = 56) | TA-TMA (n = 23) | P Value |
|---|---|---|---|
| Age, median, (IQR) | 28 (22-37) | 28 (21-37) | .255 |
| Sex | 1.000 | ||
| Female | 25 (44.6%) | 10 (43.5%) | |
| Male | 31 (55.4%) | 13 (56.5%) | |
| Disease | .359 | ||
| Acute lymphoblastic leukemia | 13 (23.2%) | 9 (39.1%) | |
| Acute myeloblastic leukemia | 33 (58.9%) | 9 (39.1%) | |
| Chronic myeloid leukemia | 2 (3.6%) | 1 (4.3%) | |
| Others | 8 (14.3%) | 4 (17.4%) | |
| HLA typing | .500 | ||
| Matched | 48 (85.7%) | 18 (78.3%) | |
| Mismatched | 8 (14.3%) | 5 (21.7%) | |
| aGVHD | .465 | ||
| Yes | 26 (46.4%) | 13 (56.5%) | |
| No | 30 (53.6%) | 10 (43.5%) | |
| Grades 2 to 4 aGVHD | 11 (19.6%) | 10 (43.5%) | .048 |
| Gastrointestinal aGVHD | 7 (12.5%) | 8 (34.8%) | .030 |
| Liver damage | 27 (48.2%) | 18 (78.3%) | .023 |
| Severe gastrointestinal bleeding | 18 (32.1%) | 17 (73.9%) | .001 |
| Severe infection | 19 (33.9%) | 19 (82.6%) | <.001 |
| Virus infection | 19 (33.9%) | 8 (34.8%) | 1.000 |
| Fungal infection | 3 (5.4%) | 8 (34.8%) | .002 |
| Fever | 13 (23.2%) | 16 (69.6%) | <.001 |
| Hypertension | 5 (8.9%) | 8 (34.8%) | .008 |
| Pulmonary hypertension | 4 (7.1%) | 9 (39.1%) | .001 |
| Death | 11 (19.6%) | 18 (78.3%) | <.001 |
| Laboratory markers | |||
| HGB, g/L, mean ± SD | 94.5 ± 27.3 | 68.2 ± 8.6 | <.001 |
| PLT, 109/L, mean ± SD | 107.2 ± 86.2 | 26.4 ± 17.8 | <.001 |
| LDH, U/L, median, (IQR) | 322.5 (235.2-423.0) | 516.0 (415.0-1078.0) | .001 |
| vWF, %, mean ± SD | 284.9 ± 104.5 | 380.7 ± 78.8 | <.001 |
| D-DI, ng/mL, median, (IQR) | 510 (290-1348) | 2450 (1030-15000) | .001 |
| Urine protein, g/L, median, (IQR) | 0.3 (0.0-0.3) | 1.0 (0.2-3.0) | .015 |
| CREA, μmol/L, mean ± SD | 83.5 ± 50.3 | 129.2 ± 74.1 | .002 |
| ALB, g/L, mean ± SD | 36.2 ± 5.8 | 32.3 ± 4.2 | .001 |
| CHE, U/L, mean ± SD | 5912.1 ± 2164.3 | 4447.1 ± 2103.1 | .007 |
| PCT, ng/mL, median, (IQR) | 0.12 (0.06-0.27) | 0.91 (0.17-2.44) | <.001 |
| CSA, ng/mL, mean ± SD | 211.6 ± 66.9 | 188.1 ± 87.2 | .206 |
| C3, mg/L, mean ± SD | 910.9 ± 247.2 | 844.2 ± 184.5 | .248 |
| C4, mg/L, mean ± SD | 226.7 ± 83.9 | 206.1 ± 45.6 | .272 |
Abbreviations: aGVHD, acute GVHD; ALB, albumin; CHE, cholinesterase; CREA, serum creatinine; CSA, cyclosporine A; D-DI, D dimer; GVHD, graft-versus-host disease; HGB, hemoglobin; HLA, human leukocyte antigen; HSCT, hematopoietic stem cell transplantation; LDH, lactate dehydrogenase; PCT, procalcitonin; PLT, platelet; SD, standard deviation; TA-TMA, transplantation-associated thrombotic microangiopathy; vWF, von Willebrand factor.
a Data with a normal distribution are represented as mean ± SD, and data with abnormal distributions are represented as median and (IQR).