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. 2020 May 8;20:823–840. doi: 10.1016/j.omtn.2020.05.003

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

In Vivo Study and the Schematic Picture of the Mechanisms in Our Study

(A) Nude mice carrying tumors from respective groups are shown. The sample tumors from respective groups are shown. (B) Tumor volume was calculated every 4 days after injection, and tumors were excised after 44 days (∗p < 0.05 versus control group; ^#p < 0.05 versus TAF15⁺ group; ^▲p < 0.05 versus LINC00665⁺ group; ^▪p < 0.05 versus MTF1⁺ group; ^●p < 0.05 versus YY2⁺ group). (C) The survival curves of nude mice injected into the right striatum. (D) The schematic picture of the mechanism in which TAF15 combined with LINC00665, thus enhancing the degradation of MTF1 and YY2 mRNA via the SMD pathway in glioma cells. Ter, translation termination codon.