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. 2020 May 16;34:101575. doi: 10.1016/j.redox.2020.101575

Table 2.

Relaxant effects of the AMPK activators AICAR and A769662 and effect of the AMPK inhibitor compound C in rat renal interlobar arteries.

pEC50 (%) Emax (%) n I1 (μm)
A769662 4.92 ± 0.05 71.9 ± 5.7 6 308 ± 16



+ Compound C 3.89 ± 0.15** 43.5 ± 6** 6 312 ± 16



AICAR 2.67 ± 0.09††† 61.8 ± 0,9 6 316 ± 17



+ Compound C 1.79 ± 0.1* 33.1 ± 13 6 326 ± 15

Values represent mean ± S.E.M. of the number n of individual arteries, 1–2 per animal. pEC50 is –logEC50, EC50 being the agonist concentration giving half-maximal relaxation; Emax = maximal relaxation (% Phe). Significant differences were analyzed by ANOVA or paired or unpaired Student t-test. *P < 0.05; **P < 0.01 versus control before treatment and †††P < 0.001 versus A769662.