Figure 5. Inhibition of hypoxia-induced activation of Wnt/β-catenin pathway by DHE in NSCLC cells.
(A) To determine the involvement of Wnt/β-catenin pathway in the effects of DHE, Western blotting analysis was performed to detect the expression levels of β-catenin, p-β-catenin, cyclinD1 and c-myc. (B–E) Quantification analysis of β-catenin, p-β-catenin, cyclinD1 and c-myc. *P<0.05. vs. A549 cells under normoxic condition. #P<0.05. vs. A549 cells under hypoxic condition.