Table 1.
Baseline characteristics of the study population.
| Total (n = 1502) | Group1 NLR ≤ 2.74 (n = 501) | Group2 2.74 < NLR ≤ 3.96 (n = 502) | Group3 NLR > 3.96 (n = 499) | P value | |
|---|---|---|---|---|---|
| No. of C1/C2/C3/C4 | 313/794/36/359 | 123/249/9/120 | 125/247/7/123 | 65/298/20/116 | <0.001 |
| No. of men/women | 852/650 | 261/240 | 270/232 | 321/178 | <0.001 |
| NLR | 3.3 (2.5, 4.5) | 2.2 (1.8, 2.5) | 3.3 (3.0, 3.6) | 5.4 (4.5, 7.0) | <0.001 |
| Demographics | |||||
| Age (y) | 51.0 (41.0, 62.0) | 49.0 (39.0, 61.0) | 50.5 (41.0, 61.0) | 53.0 (43.0, 63.0) | 0.008 |
| BMI (kg/m2) | 22.1 (20.1,24.2) | 22.1 (20.0, 24.2) | 22.1 (20.3, 24.4) | 22.1 (20.1, 24.2) | 0.400 |
| Comorbid | |||||
| Systolic BP (mmHg) | 146.0 (132.0, 164.0) | 146.0 130.0, 160.0) | 146.0 (134.0, 161.0) | 149.0 (134.0, 170.0) | <0.001 |
| Diastolic BP (mmHg) | 86.0 (78.0, 95.0) | 86.0 (78.0, 95.0) | 86.0 (79.0, 95.0) | 86.0 (78.0, 96.0) | 0.537 |
| Hypertension | 985 (65.6%) | 310 (61.9%) | 319 (63.5%) | 356 (71.3%) | 0.004 |
| Diabetes mellitus | 343 (22.8%) | 106 (21.2%) | 115 (22.9%) | 122 (24.4%) | 0.463 |
| Cardiovascular disease | 232 (15.4%) | 68 (13.6%) | 77 (15.3%) | 87 (17.4%) | 0.239 |
| Treatments | |||||
| CCB | 1104 (73.5%) | 369 (73.7%) | 367 (73.1%) | 368 (73.7%) | 0.970 |
| Loop diuretic | 100 (6.7%) | 32 (6.4%) | 30 (6.0%) | 38 (7.6%) | 0.557 |
| Insulin | 231 (15.4%) | 75 (15.0%) | 71 (14.1%) | 85 (17.0%) | 0.427 |
| Laboratory variables | |||||
| WBC (109/L) | 6.1 (4.9, 7.6) | 5.3 (4.3, 6.6) | 6.1 (5.0, 7.3) | 6.9 (5.7, 9.0) | <0.001 |
| Neutrophil (109/L) | 4.1 (3.1, 5.2) | 3.0 (2.4, 3.8) | 4.1 (3.5, 4.8) | 5.3 (4.2, 6.9) | <0.001 |
| Lymphocyte (109/L) | 1.2 (0.9, 1.6) | 1.5 (1.2, 1.9) | 1.2 (1.0, 1.5) | 0.9 (0.7, 1.2) | <0.001 |
| Hemoglobin (g/L) | 87.0 (74.0, 100.0) | 89.0 (76.0, 103.0) | 87.0 (75.0, 101.0) | 83.0 (70.0, 95.0) | <0.001 |
| Albumin (g/L) | 34.6 (31.1, 37.9) | 34.9 (31.4, 38.4) | 34.7 (31.3, 37.4) | 34.2 (30.7, 37.6) | 0.046 |
| Creatinine (μmol/L) | 708.1 (543.8, 931.1) | 699.0 (543.5, 898.5) | 713.0 (542.0, 932.7) | 728.0 (546.0, 948.8) | 0.606 |
| Urea nitrogen (mmol/L) | 20.5 (15.5, 26.8) | 19.5 (15.2, 25.4) | 20.2 (15.3, 26.4) | 21.8 (16.3, 29.4) | <0.001 |
| Uric acid (mmol/L) | 428.0 (356.0, 508.3) | 428.0 (356.0, 511.5) | 428.0 (355.0, 504.0) | 428.0 (360.0, 504.0) | 0.891 |
| FBG (mmol/L) | 4.7 (4.1, 5.5) | 4.6 (4.1, 5.4) | 4.7 (4.1, 5.5) | 4.8 (4.1, 5.6) | 0.033 |
| Cholesterol (mmol/L) | 4.2 (3.5, 5.0 | 4.3 (3.7, 5.0) | 4.2 (3.5, 4.9) | 4.2 (3.4, 4.9) | 0.009 |
| Triglycerides (mmol/L) | 1.3 (1.0, 1.8) | 1.3 (1.0, 1.8) | 1.3 (1.0, 1.8) | 1.3 (0.9, 1.7) | 0.029 |
| Sodium (mmol/L) | 140.1 (138.0, 142.3) | 140.6 (138.3, 142.5) | 140.0 (138.0, 142.9) | 140.0 (137.7, 142.0) | 0.017 |
| Chlorine (mmol/L) | 103.0 (99.4, 107.0) | 103.2 (99.9, 107.0) | 103.0 (99.3, 106.8) | 102.8 (99.0, 107.0) | 0.103 |
| Calcium (mmol/L) | 2.0 (1.9, 2.2) | 2.1 (1.9, 2.2) | 2.0 (1.9, 2.2) | 2.0 (1.8, 2.1) | <0.001 |
| Potassium (mmol/L) | 4.1 (3.6, 4.7) | 4.2 (3.7, 4.8) | 4.1 (3.6, 4.7) | 4.1 (3.6, 4.7) | 0.226 |
| Phosphorus (mmol/L) | 1.7 (1.4, 2.0) | 1.7 (1.4, 2.0) | 1.7 (1.3, 2.0) | 1.7 (1.4, 2.1) | 0.005 |
| Total Kt/V | 2.2 (1.8, 2.6) | 2.2 (1.8, 2.7) | 2.2 (1.7, 2.6) | 2.2 (1.8, 2.6) | 0.099 |
| RRF(mL/min) | 3.9 (2.1, 7.2) | 3.9 (2.0, 7.6) | 3.9 (2.2, 7.1) | 3.9 (2.0, 6.8) | 0.856 |
Note: All continuous variables are skewed distribution, the values for continuous variables are given as median (P25, P75). Abbreviations: C1: center 1; C2: center 2; C3: center 3; C4: center 4; NLR: neutrophil lymphocyte ratio; BMI: body mass index; BP: blood pressure; CCB: calcium channel blocker; WBC: white blood cell; FBG: fasting blood glucose; Kt/V: K, dialyzer clearance of urea; t, dialysis time; V, volume of distribution of urea; RRF: renal residual function.