Table II.

Example of single nucleotide polymorphism informativity results for an autosomal dominant disorder.

Affected male partner	Unaffected female partner	Informativity	ADO detection in the embryo	Detection of maternal contamination	Additional info on monosomy/trisomy	Comments	Recommendation for PGT-M (ranking1)
A*B	AA	Informative	Partially	No	Partially	The wild-type allele is a unique allele, therefore unaffected embryos are heterozygous and can be distinguished	Preferred marker (1)
AB*	BB
AB*	AA	Informative	Partially	No	Partially	The mutant allele is a unique allele therefore unaffected embryos are homozygous; therefore, it is uncertain whether both paternal and maternal alleles are present	Usable marker (2)
A*B	BB
A*B or AB*	AB	Non-informative	No	No	No	The marker yields very limited information (to be used in combination with other markers)	Usable marker (3)
AA or BB	Any genotype	Non-informative	-	-	-	No information	Not recommended

¹The utility of the markers is ranked from very good (1) to very low (3)

The pathogenic allele is indicated with ^*after validation of segregation with a suitable reference.