Fig. 4.

The effects of COG1410 on microglia/macrophage activation and neutrophil infiltration after ICH. a, d Representative images of immunofluorescence staining of Iba-1 (green) and MPO (green) in the perihematomal area at 24 h after ICH. b, e Brain sample with schematic illustration showing the area (indicated by black squares) used for Iba-1 and MPO-positive cell counting in the perihematomal region. c, f Quantitative analyses of Iba-1 and MPO-positive cells in the perihematomal area at 24 h after ICH. g, h Representative western blot bands and quantitative analyses of TNF-α and IL-1β protein levels in the ipsilateral hemisphere at 24 h after ICH. *p < 0.05 vs. sham, ^#p < 0.05 vs. ICH + vehicle. Error bars are represented as mean ± SD. n = 6 per group