Fig. 8.

TREM2 knockdown and PI3K inhibition reversed the effects of COG1410 on neurological functions and inflammatory/apoptotic proteins expression. a–c The modified Garcia test, corner turn, test and forelimb placement test of each group at 24 h after ICH. d Representative western blot bands. e–k Quantitative analyses of TREM2, PI3K, phosphorylated Akt, TNF-α, IL-1β, Bcl-2, and Bax in the ipsilateral hemisphere at 24 h after ICH. *p < 0.05 vs. sham, ^#p < 0.05 vs. ICH + vehicle, ^@p < 0.05 vs. ICH + COG1410 + TREM2 siRNA, ^&p < 0.05 vs. ICH + COG1410 + LY294002. Error bars are represented as mean ± SD. n = 6 per group