Table 5.

Secondary analysis: PD-L1

PD-L1 density (mm2/mm2)	Rituximab Mean (95% CI)	Controls Mean (95% CI)	p
Tumor region	0.059 (0.018, 0.099)	0.083 (0.040, 0.127)	0.36
Non-neoplastic region	0.054 (0.004, 0.103)	0.132 (0.056, 0.321)	0.39
Within group difference
Tumor − non-neoplastic	0.005 (− 0.012, + 0.022)	− 0.049 (− 0.248, + 0.151)	0.56

1. Density of tumor for subjects treated with rituximab

2. Density of adjacent normal tissue for subjects treated with rituximab

3. Use one sample t test to get the mean and 95% CI

4. p value is from two sample t-test

For two sample t-test, the Welch (or Satterthwaite) approximation to the degrees of freedom is used

Null hypothesis is no difference

5. (Tumor − normal) is calculated by: column K − column L