Fig. 1.

Nominated candidate targets and their correlation to AD biomarkers. a Volcano plot displaying the log₂ fold-change (x-axis) against significance,  −log₁₀ p value, for all proteins (n = 2875), including those differentially expressed between control and AD cases of the TMT discovery. Proteins above the dashed line (> 1.3) on the y-axis are statistically significant (p < 0.05). Proteins that are depicted in red (increased) or blue (decreased) denote the 41 significantly different proteins quantified by PRM in this study. b Correlation of all proteins quantified in the TMT discovery cohort (n = 2785) with paired ELISA measures of t-tau, pTau, Aβ, and Aβ/Tau ratio. Proteins highlighted in red or blue reflect the 41 targets either positively or negatively correlated to the ELISA values. All protein correlations and p-values are provided in Additional file 1: Table S8