Fig. 2.

TVGV-HBx exerts therapeutic function in HBV carrier mice. HBV carrier mice (N = 5 ~ 8) received TVGV-HBx, TVGV-E7, CpG-ODN alone or PBS on days 0, 7 and 14. Mouse serum was sampled on days 0, 7, 14, 21, 32, 39 and 46, and liver samples were collected on day 70. a Serum HBs titers were determined. b Serum HBV-DNA was detected. c Serum anti-HBs titer on day 39. d Liver HBc was detected by western blotting. e Liver HBV-DNA was detected. The value of the undetectable Q-PCR sample was assigned as the detection limit for plotting. Statistics: Student’s t-test. *, p < 0.05; **, p < 0.01; ***, p < 0.001; LoD, limit of detection