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. 2020 May 28;27:70. doi: 10.1186/s12929-020-00662-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Liver monocyte subpopulation changes after TVGV-HBx vaccination and monocyte-depleting drug treatment. a-b HBV carrier mice (N = 4) received TVGV-HBx on day 0. Gemcitabine (40 mg/kg) was given by intraperitoneal injection on days 0 and 1. CLs (200 μL) were given by intravenous injection on day 0. Total intrahepatic leukocytes were collected on day 2 and subjected to flow cytometric analysis. The isolated cell count of each cell subpopulation was calculated by multiplying the actual isolated CD45⁺ leukocyte count per liver by the subpopulation frequency among isolated cells. a Total isolated cell count of all F4/80^lowCD11b⁺Ly6G⁻ monocytes. b Total isolated cell counts of the indicated monocyte subsets and F4/80^highCD11b⁺ KCs. c Schematic Venn diagram of liver myeloid cell subpopulations depleted by CL or gemcitabine treatment. Statistics: Student’s t-test. *, p < 0.05; **, p < 0.01; NS, not significant