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. 2020 May 29;17:170. doi: 10.1186/s12974-020-01851-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Deletion of TDAG8 gene attenuates mechanical and thermal hyperalgesia and reduces arthritis scores. TDAG8+/+, +/−, −/− mice (8–12 weeks old) were injected with 5 μl of 100% CFA (5 μg) in the right ankle joint (ipsilateral joint) four times at 1-week intervals, then underwent mechanical (a, b) or thermal (c, d) behavioral tests. Arrows are CFA treatments. Data are mean ± SEM of total tested mice. *p < 0.05, **p < 0.01, ***p < 0.001, TDAG8^−/− (n = 5) vs TDAG8^+/+ (n = 3), or TDAG8^−/− (n = 10) vs TDAG8^+/− (n = 3). e Severity of arthritis presented as arthritis score. *p < 0.05, **p < 0.01, ***p < 0.001, TDAG8^−/− (n = 10) vs TDAG8^+/+ (n = 3) by two-way ANOVA. f IL-6 production at 12 w after the first CFA injection in TDAG8^+/+ and TDAG8^−/− mice. ***p < 0.001, TDAG8^−/− (n = 3) vs TDAG8^+/+ (n = 3) by Mann-Whitney U test. g IL-17 production at 8 and 12 weeks after the first CFA injection in TDAG8^+/+ and TDAG8^−/− mice. *p < 0.05, TDAG8^−/− (n = 6) vs TDAG8^+/+ (n = 4) by two-way ANOVA