TABLE 3.

ANX2, SPINK1, and Hsp60 expression assessment of adjacent modified WHO levels or WHO levels

Group comparisons	Annexin 2 H score mean (95%CI)	SPINK1 H score mean (95%CI)	HSP60 H score mean (95%CI)
WHO 1a (Normal)	11.1 (9.4–12.8)	1.93 (0.33–3.5)	4.7 (3.2–6.2)
WHO 1b (Gleason 2–6)	5.3 (3.5–7.1)	7.90 (5.7–10.1)	6.17 (4.0–8.4)
P(difference*)	P < 0.0000	P < 0.0001	P = 0.25
WHO 1b (Gleason 2–6)	5.3 (3.5–7.1)	7.9 (5.7–10.1)	6.2 (4.0–8.4)
WHO 2 (Gleason 3 + 4)	3.4 (2.1–4.7)	7.1 (4.8–9.4)	9.3 (7.3–11.3)
P(difference*)	P = 0.08	P = 0.60	P = 0.03
WHO 2 (Gleason 3 + 4)	3.4 (2.1–4.7)	7.1 (4.8–9.4)	9.3 (7.3–11.3)
WHO 3 (Gleason 4 + 3)	2.6 (1.3–3.9)	5.9 (3.1–8.8)	7.7 (4.3–11.1)
P(difference*)	P = 0.37	P = 0.48	0.37
WHO 3 (Gleason 4 + 3)	2.6 (1.3–3.9)	5.9 (3.1–8.8)	7.7 (4.3–11.1)
WHO 4 (Gleason 4 + 4)	1.2 (0.81–1.7)	5.3 (2.8–7.9)	9.8 (7.6–12.1)
P(difference*)	P = 0.02	P = 0.75	0.25
WHO 4 (Gleason 4 + 4)	1.2 (0.81–1.7)	5.3 (2.8–7.9)	9.8 (7.6–12.1)
WHO 5 (Gleason 9–10)	1.3 (0.77–1.9)	6.8 (3.7–10.0)	9.4 (6.3–12.5)
P(difference*)	P = 0.75	P = 0.43	P = 0.79
All Levels of WHO
Category	0.7122	0.2139	0.1980
P(F test)**	P < 0.0000	P = 0.0028	P = 0.0052

^*T test (Stata) two tailed test.

^**One way ANOVA two tailed test.