Fig. 10.

Post-injury delivery of recombinant human TRIM72 protein (rhT72) reduces mortality and prevents lung fibrosis in bleomycin (bleo)-exposed mice. a intraperitoneal injection of rhT72 at post-injury days 7–11 ameliorates the mortality in bleo-treated mice. Kaplan-Meier survival curves were created for bleo-exposed rhT72- or control protein-treated mice (n = 18 for MBP control group and = 10 for rhT72 group). Black arrow indicates the administration of rhT72 or CTRL protein. The Mantel-Cox Log Rank test yields a p = 0.0469; b Masson’s trichrome staining in 1.5 U/kg body weight bleo-treated B6 WT received CTRL or rhT72 protein at post-injury days 7–11. Scale bar = 100 μm