Fig. 6.

TRIM72 inhibits bleomycin (bleo)-induced ATII cell apoptosis. a Representative TUNEL, SFTPC, and cleaved caspase-3 (Casp-3) immunostaining on doxycycline (Dox)-injected bleo-treated WT and TRIM72 overexpressor (T72OE) lungs; scale bar = 100 μm; b quantification of the number of apoptotic cells (TUNEL+); c percentage of apoptotic ATII cells (SFTPC positive) among TUNEL positive cells, and apoptotic ATII cells among total ATII cells in PBS- or bleo-treated lungs; data = mean ± SEM, n = 3 for WT and T72OE PBS and n = 6 for WT and T72OE bleo groups, *P < 0.05 or **P < 0.01 compared to WT based on two-tailed student t-tests, or one-way ANOVA with post hoc analysis for comparison among different groups