Table 1.

Characteristics of studies included in meta-analysis

Study author	Year	Country	Ethnicity	Total cases/controls	Sex cases/controls	Genotyping method	Mean age Cases/Controls	Quality score
MMP9
Nelissen et al.	2000	Sweden	European	199/146	M = NR F=NR	PCR-RFLP	NR/NR	6
Zivkovic et al.	2007	Serbia	European	187/282	M = 67/140 F = 120/142	Touch Down PCR	35.5 ± 10.1/40.8 ± 14.8	7
Benesova et al.	2008	Czech Republic	European	244/132	M = 63/45 F = 181/87	PCR-SSP	38.4 ± 10.2/35.6 ± 11.7	7
Mirowska-Guzel et al.	2009	Poland	European	234/190	M = 66/76 F = 168/114	PCR-RFLP	40.09 ± 10.19/40.09 ± 10.19	7
Fernandes et al.	2009	Brazil	South-American	158/191	M = 41/54 F = 117/137	PCR-RFLP	38.7 ± 13/35.6 ± 9.5	6
La Russa et al.	2010	Italy	European	243/173	M = 96/107 F = 147/66	PCR-RFLP	41.1 ± 12.2/28.5 ± 9.4	7
Valado et al.	2017	Portugal	European	169/183	M = 48/63 F = 121/120	PCR-RFLP	41.44 ± 0.84/39.09 ± 0.96	6
Ibrahim et al.	2019	Egypt	African	50/100	M = 18/NR F = 32/NR	PCR-RFLP	32.9 ± 8.1/NR	5
Sabbagh et al.	2019	Iran	Asian	100/105	M = 37/41 F = 63/64	PCR-ARMS	42.89 ± 10.48/46.52 ± 8.90	5
Sadr et al.	2019	Iran	Asian	170/200	M = 121/142 F = 49/58	PCR-RFLP	33.34 ± 7.91/31.88 ± 9.79	7
MMP3
Djuric et al.	2008	Serbia	European	184/236	M = NR F=NR	Touch Down PCR	NR/NR	7
Rahimi et al.	2016	Iran	Asian	121/106	M = 24/17 F = 97/89	PCR-RFLP	35.3 ± 9.1/34.5 ± 11.4	6
MMP2
Benesova et al.	2008	Czech Republic	European	240/132	M = 60/45 F = 180/87	PCR-SSP	38.4 ± 10.2/35.6 ± 11.7	7
Aksoy et al.	2016	Turkey	European	102/102	M = 76/75 F = 26/27	Taq man	36.69 ± 8.33/35.93 ± 8.20	6
Liutkeviciene et al.	2018	Lithuania	European	26/26	M = NR F=NR	Taq man	36/34	5