Table 2.

Distribution of genotype and allele frequencies among MS patients and controls

Study author	MS cases					Healthy control					P-HWE	MAF
	CC	CT	TT	C	T	CC	CT	TT	C	T
MMP9
Nelissen et al.	143	51	5	337	61	102	40	4	244	48	0/973	0/164
Zivkovic et al.	146	41	0	333	41	200	74	8	474	90	0/716	0/16
Benesova et al.	191	50	3	432	56	87	42	3	216	48	0/424	0/182
Mirowska-Guzel et al.	128	103	3	359	109	136	50	4	322	58	0/811	0/153
Fernandes et al.	117	35	6	269	47	156	32	3	344	38	0/369	0/099
La Russa et al.	164	73	6	401	85	147	25	1	319	27	0/954	0/078
Valado et al.	130	35	4	295	43	145	34	4	324	42	0/247	0/115
Ibrahim et al.	28	21	1	77	23	78	21	1	177	23	0/751	0/115
Sabbagh et al.	11	35	54	57	143	42	42	21	126	84	0/087	0/4
Sadr et al.	96	60	14	252	88	163	33	4	359	41	0/144	0/103
MMP2
Benesova et al.	143	84	13	370	110	75	40	17	190	74	0.004	0.28
Aksoy et al.	40	56	6	136	68	77	25	0	179	25	0.15	0.123
Liutkeviciene et al.	19	7	0	45	7	190	108	20	488	148	0.38	0.233
Study author	MS cases					Healthy control					P-HWE	MAF
	5A/5A	5A/6A	6A/6A	5A	6A	5A/5A	5A/6A	6A/6A	5A	6A
MMP3
Djuric et al.	24	102	58	150	218	37	130	69	204	268	0.06	0.568
Rahimi et al.	3	66	52	72	170	1	67	38	69	143	0.006	0.675

P-HWE, p-value for Hardy–Weinberg equilibrium; MAF Minor allele frequency of control group