Table 3.
Main results of pooled ORs in meta-analysis of MMP family gene polymorphism
| Subgroup | Sample size | Test of association | Test of heterogeneity | Test of publication bias (Begg’s test) | Test of publication bias (Egger’s test) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genetic model | Case/Control | OR | 95%CI(P-value) | I2 (%) | P | Z | P | T | P | |
| MMP9 | ||||||||||
| Overall | Dominant | 1754 / 1702 | 1.62 | 1.03– 2.53 (0.03) | 85.5 | ≤0.001 | 0.80 | 0.42 | 1.27 | 0.24 |
| Recessive | 1754 / 1702 | 2.69 | 1.68 – 4.29 (≤0.001) | 27 | 0.20 | -1.46 | 0.14 | -2.17 | 0.06 | |
| Allelic | 1754 / 1702 | 1.51 | 1- 2.28 (0.04) | 87.8 | ≤0.001 | 0.27 | 0.78 | 0.34 | 0.74 | |
| TT vs. CC | 1754 / 1702 | 3.20 | 1.87 – 5.46 (≤0.001) | 50 | 0.04 | -1.04 | 0.29 | -1.90 | 0.9 | |
| CT vs.CC | 1754 / 1702 | 1.53 | 1.02 – 2.28 (0.04) | 80.8 | ≤0.001 | 0.98 | 0.32 | 1 | 0.34 | |
| MMP3 | ||||||||||
| Dominant | 305/342 | 1.18 | 0.66-2.13 (0.57) | 0 | 0.57 | -1 | 0.31 | * | * | |
| Recessive | 305/342 | 0.57 | 0.18-1.79 (0.33) | 88.5 | ≤0.001 | 1 | 0.31 | * | * | |
| Allelic | 305/342 | 1.11 | 0.88-1.41 (0.39) | 0 | 0.91 | 1 | 0.31 | * | * | |
| 6A6A vs. 5A5A | 305/342 | 1.15 | 0.62- 2.11 (0.43) | 0 | 0.48 | -1 | 0.31 | * | * | |
| 5A6A vs.5A5A | 305/342 | 1.24 | 0.64 – 2.39 (0.52) | 0 | 0.54 | 1 | 0.31 | * | * | |
| MMP2 | ||||||||||
| Overall | Dominant | 368 /552 | 1.36 | 0.39 – 4.78 (0.07) | 90.4 | ≤0.001 | 0.52 | 0.60 | 0.04 | 0.97 |
| Allelic | 368 /552 | 1.15 | 0.36 – 3.61 (0.81) | 91.9 | ≤0.001 | 0.52 | 0.60 | 0.14 | 0.91 | |
| CT vs.CC | 368 /552 | 1.50 | 0.52 – 4.35 (0.45) | 85.9 | ≤0.001 | 0.52 | 0.60 | -0.10 | 0.93 | |
* Egger’s test was not calculable