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Effects of LA and A-LA on IL-1β + OSM-induced NO production (a) and s-GAG release (b). Cartilage explants were stimulated for 14 days, supernatants collected and NO and s-GAG concentrations were determined by colorimetric reactions. For PG loss, results are expressed as ng s-GAG per mg tissue. Data represent mean ± SEM (n = 6). *p ⩽ 0.05, **p ⩽ 0.01, *p ⩽ 0.001 versus IL-1β + OSM group.
