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. 2020 May 27;11:2041731420924818. doi: 10.1177/2041731420924818

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — MailPan^® filled with RIN-m5F cells can correct diabetes in STZ-induced rats: (a) Body weight gain follow-up; (b) AUC calculated from weight gain values of the whole follow-up of rats that received RIN-m5F cells in MailPan^® (RIN group n = 6), healthy control (n = 3), and diabetic control (n = 4). Mean ± SEM. *p < 0.05; **p < 0.01 one-way ANOVA. On graph A, black arrow indicates the time (D14) when exogenous insulin therapy was stopped; (c) fasting glycemia of rats that received RIN-m5F cells in MailPan^® (RIN group n = 6), healthy control (n = 3), and diabetic control (n = 4). Mean ± SEM. ***p < 0.001 vs diabetic control, two-way ANOVA; (d) viability of cell clusters recovered from the MailPan^® of each recipient after 10 weeks. Viability expressed in percent was calculated using live/dead staining. Each point represents a cluster analyzed; horizontal bar shows mean value with SEM as error bars; and (e) representative picture of Live/dead staining performed on cells cluster recovered after 10 weeks in the device. From left to right are presented pictures of bright filed, calcein AM staining (live cells) and Ethidium Homodimer-1 staining (dead cells). Scale bar represents 200 µm.