Figure 3.

Backtracking in DPO4 folding. (A) The evolutions of native contact formation of DPO4 during folding under different confinements. Q(intra) (dashed lines) and Q(inter) (solid lines) are the fractions of intra- and interdomain contacts, respectively. (B) 2D free energy landscape projected onto Q(total) and Q(inter). Two parallel pathways are identified by proceeding through two different transition states (TS₁ and TS₂). (C) Evolutions of the native contact map in the two parallel folding pathways. Within the bottom-right triangle of each contact map panel, one representative DPO4 structure for the corresponding state is shown.