Table 3. Patients without history of neurosurgery who had no periodic sharp-wave complexes during duration of CJD and hyperintensity lesions in thalamus diffusion-weighted magnetic resonance imaging of the brain*.
Patient no. | Age at CJD onset, y/sex | Codon 129 of PRNP | Hyperintensity lesions on DW-MRI | Pathology findings |
---|---|---|---|---|
1 | 58/F | MM | CC, BG, Th | MM2+1 |
2 | 65/M | MM | CC, Th | MM2+1 |
3 | 61/F | MM | CC, BG, Th | ND |
4 | 58/M | MV | BG, Th | MV2 |
5 | 73/F | MV | CC, Th | MV2 |
6 | 65/F | MV | CC, BG, Th | ND |
7 | 65/F | MV | CC, Th | ND |
8 | 75/F | VV | BG, Th | VV2 |
9 | 69/M | VV | BG, Th | VV2 |
10 |
52/M |
VV |
CC, BG, Th |
ND |
*BG, basal ganglia; CC, cerebral cortex; CJD, Creutzfeldt-Jakob disease; DW-MRI, diffusion-weighted magnetic resonance imaging; MM, methionine homozygous; MM2+1, pathological features of MM2 and MM1 types of sporadic CJD; MV, methionine-valine; Th, thalamus; VV, valine homozygous. |