Table 4. Minimal inhibitory concentrations of 5 antifungal drugs for Fonsecaea nubica) and Cladophialophora carrionii (n = 5) strains, Madagascar*.
| Fungi, drug | MIC, μg/mL and no. isolates |
Geometric mean, μg/mL (range) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.008 | 0.015 | 0.02 | 0.031 | 0.062 | 0.125 | 0.25 | 0.5 | 1.0 | 2.0 | ||
| F. nubica, n = 15 | |||||||||||
| ITZ | 0 | 0 | 0 | 5 | 3 | 4 | 1 | 1 | 1 | 0 | 0.101 (0.031–1.0) |
| PSZ | 0 | 11 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0.021 (0.015–0.062) |
| ISZ | 1 | 3 | 0 | 10 | 1 | 0 | 0 | 0 | 0 | 0 | 0.027 (0.008–0.006) |
| TRB | 11 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.012 (0.008–0.003) |
| AMB |
0 |
0 |
0 |
0 |
1 |
2 |
4 |
6 |
1 |
1 |
0.692 (0.062–4.0) |
| C. carrionii, n = 5 | |||||||||||
| ITZ | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 1 | 0 | 0 | 0.094 (0.031–1.0) |
| PSZ | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0.071 (0.031–0.5) |
| ISZ | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0.071 (0.031–0.5) |
| TRB | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0.024 (0.008–0.125) |
| AMB | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 4.595 (2.0–8.0) |
*AMB, amphotericin B; ISZ, isavuconazole; ITZ, itraconazole; PSZ, posaconazole; TRB, terbinafine.