Table 4. Characteristics of cases of invasive pneumococcal disease caused by serotype 3 in patients 2–59 months of age with vaccine failure or unvaccinated, Catalonia, Spain, 2012–2016*.
| Variable | Vaccine failure, no. (%), n = 16 | Unvaccinated, no. (%), n = 20 | OR (95% CI) | p value |
|---|---|---|---|---|
| Sex | ||||
| F | 5 (31.3) | 6 (30.0) | Referent | |
| M |
11 (68.8) |
14 (70.0) |
0.94 (0.23–3.92) |
0.936 |
| Days of admission, mean (SD) | 14.69 (9.81) | 12.25 (6.07) | 1.04 (0.95–1.13) | 0.367 |
| ICU days, mean (SD) |
1.00 |
3.00 (1.14) |
Not calculable |
0.540 |
| Age group | ||||
| 0–23 mo | 3 (18.8) | 7 (35.0) | Referent | |
| 24–59 mo |
13 (81.3) |
13 (65.0) |
2.33 (0.49–11.06) |
0.456 |
| Clinical form | ||||
| Septic shock | 0 | 1 (5.0) | 0 | 0 |
| Uncomplicated pneumonia | 0 | 2 (10.0) | 0 | 0 |
| Complicated pneumonia | 15 (93.8) | 17 (85.0) | 2.65 (0.25–28.24) | 0.613 |
| Mastoiditis |
1 (6.3) |
0 |
0 |
0 |
| Empyema | ||||
| No | 3 (20.0) | 3 (17.6) | Referent | |
| Yes |
12 (80.0) |
14 (82.4) |
0.86 (0.15–5.06) |
1.000 |
| Pleural effusion | ||||
| No | 14 (93.3) | 13 (76.5) | Referent | |
| Yes |
1 (6.7) |
4 (23.5) |
0.23 (0.02–2.36) |
0.338 |
| Necrotizing pneumonia | ||||
| No | 9 (60.0) | 13 (76.5) | Referent | |
| Yes |
6 (40.0) |
4 (23.5) |
2.17 (0.47–9.95) |
0.450 |
| ICU | ||||
| No | 15 (93.8) | 18 (90.0) | Referent | |
| Yes |
1 (6.3) |
2 (10.0) |
0.60 (0.05–7.28) |
1.000 |
| Sequelae at discharge | ||||
| No | 13 (81.3) | 17 (85.0) | Referent | |
| Yes |
3 (18.8) |
3 (15.0) |
1.31 (0.23–7.57) |
1.000 |
| Underlying disease | ||||
| No | 16 (100.0) | 19 (95.0) | ||
| Yes |
0 |
1 (5.0) |
|
|
| PCR diagnosis only | ||||
| No | 1 (6.3) | 2 (10.0) | Referent | |
| Yes | 15 (93.8) | 18 (90.0) | 1.67 (0.14–20.23) | 1.000 |
*ICU, intensive care unit.